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Oral Administration of CBD Improves Histopathological and Cognitive Outcomes Following Traumatic Brain Injury

Meghan Blaya
University of Miami

Objective: Traumatic brain injury (TBI) is a leading cause of death and disability with 69 million individuals sustaining TBI each year. Long-term complications, such as cognitive impairment, headache, sleep disturbances, and neurological comorbidities are primary complaints. Currently, there is a severe lack of treatment options to lessen the negative impact injury-induced disorders have on quality of life. Cannabidiol (CBD) is a nonpsychoactive, plant-derived compound that has beneficial outcomes in several nervous system disorders due to its anti-inflammatory and anti-apoptotic properties. Thus, we sought to evaluate a clinically-relevant oral administration of CBD to investigate its potential to reverse TBI-induced pathology in a preclinical model of TBI.

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