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The effect of Cannabis compound tetrahydrocannabinol on fibrotic pathways; implications beyond fibrosis

Christopher Broxson
University of Florida

Objective: Cannabis use by patients with inflammatory bowel disease (IBD) has become increasingly popular. Cannabis improves symptoms but may increase the need for surgery in patients with Crohn’s disease (CD). Previously, our group has shown tetrahydrocannabinol (THC), a primary constituent of cannabis, inhibits pro-fibrotic gene expression in human intestinal myofibroblasts (hIMF). Here we studied the mechanism of the major fibrotic signaling pathway involving the TGF-1/Smad family of proteins.

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